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An opioid analgesic with central action, tapentadol is used to treat moderate to severe pain. While tapentadol and tramadol share a similar structural makeup, tapentadol functions differently. Tapentadol is categorized as an inhibitor of norepinephrine reuptake and an opioid agonist. In order to reduce pain, tapentadol binds to opioid receptors in the central nervous system. It also increases norepinephrine’s analgesic effects by blocking its reuptake.
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